Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells

Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells

5-Methylcytosine (5mC) is an epigenetic modification involved in regulation of gene activity during differentiation. Tet dioxygenases oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Both 5fC and 5caC can be excised from DNA by thymine-DNA glycosy...

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Bibliographic Details
Main Authors: Lee M. Wheldon, Abdulkadir Abakir, Zoltan Ferjentsik, Tatiana Dudnakova, Stephanie Strohbuecker, Denise Christie, Nan Dai, Shengxi Guan, Jeremy M. Foster, Ivan R. Corrêa, Jr., Matthew Loose, James E. Dixon, Virginie Sottile, Andrew D. Johnson, Alexey Ruzov
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003787

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http://www.sciencedirect.com/science/article/pii/S2211124714003787

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