Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.

Single genome sequencing of early HIV-1 genomes provides a sensitive, dynamic assessment of virus evolution and insight into the earliest anti-viral immune responses in vivo. By using this approach, together with deep sequencing, site-directed mutagenesis, antibody adsorptions and virus-entry assays...

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Bibliographic Details
Main Authors: Katharine J Bar, Chun-yen Tsao, Shilpa S Iyer, Julie M Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C Montefiori, Hua-Xin Liao, Peter Hraber, William Fischer, Hui Li, Shuyi Wang, Sarah Sterrett, Brandon F Keele, Vitaly V Ganusov, Alan S Perelson, Bette T Korber, Ivelin Georgiev, Jason S McLellan, Jeffrey W Pavlicek, Feng Gao, Barton F Haynes, Beatrice H Hahn, Peter D Kwong, George M Shaw
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3364956?pdf=render

Internet

http://europepmc.org/articles/PMC3364956?pdf=render

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