Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

<p>Abstract</p> <p>Background</p> <p>Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies. The soybean isoflavone, genistein (GE), has been shown to prevent and inhibit...

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Bibliographic Details
Main Authors: Li Yuanyuan, Meeran Syed M, Patel Shweta N, Chen Huaping, Hardy Tabitha M, Tollefsbol Trygve O
Format: Article
Language:English
Published: BMC 2013-02-01
Series:Molecular Cancer
Subjects:
Genistein
ERα
Tamoxifen
Epigenetic
Breast cancer
Online Access:http://www.molecular-cancer.com/content/12/1/9

Internet

http://www.molecular-cancer.com/content/12/1/9

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