The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach

Autophagy failure is implicated in age-related human disease. A decrease in the rate of protein degradation through the entire autophagy pathway, i.e., autophagic flux, has been associated with the onset of cellular proteotoxity and cell death. Although the precision control of autophagy as a pharma...

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Bibliographic Details
Main Authors: André du Toit, Sholto De Wet, Jan-Hendrik S. Hofmeyr, Kristian K. Müller-Nedebock, Ben Loos
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Cells
Subjects:
Online Access:http://www.mdpi.com/2073-4409/7/8/94