Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione- Based Compounds

Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione- Based Compounds

The anticonvulsant activity of several 1,2,4-triazole-3-thione derivatives on mouse maximal electroshock-induced seizures was tested in this study. Characteristic features of all active compounds were rapid onset of action and long lasting effect. Structure-activity observations showed that the prob...

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Bibliographic Details
Main Authors: Tomasz Plech, Barbara Kaproń, Jarogniew J. Łuszczki, Monika Wujec, Agata Paneth, Agata Siwek, Marcin Kołaczkowski, Maria Żołnierek, Gabriel Nowak
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
30-688 s-triazoles
Mannich bases
maximal electroshock-induced seizure (MES) test
blood-brain barrier (BBB)
radioligand binding assay
Online Access:http://www.mdpi.com/1420-3049/19/8/11279

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http://www.mdpi.com/1420-3049/19/8/11279

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