Safety of a Novel Listeria monocytogenes-Based Vaccine Vector Expressing NcSAG1 (Neospora caninum Surface Antigen 1)

Safety of a Novel Listeria monocytogenes-Based Vaccine Vector Expressing NcSAG1 (Neospora caninum Surface Antigen 1)

Listeria monocytogenes (LM) has been proposed as vaccine vector in various cancers and infectious diseases since LM induces a strong immune response. In this study, we developed a novel and safe LM-based vaccine vector platform, by engineering a triple attenuated mutant (Lm3Dx) (ΔactA, ΔinlA, ΔinlB)...

Full description

Bibliographic Details
Main Authors: William Robert Pownall, Dennis Imhof, Nerea Fernandez Trigo, Stephanie C. Ganal-Vonarburg, Philippe Plattet, Camille Monney, Franck Forterre, Andrew Hemphill, Anna Oevermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
microbial vaccine
Listeria monocytogenes
neosporosis
Neospora caninum
immune response
in vitro safety
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.675219/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.675219/full

Similar Items