MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats

MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats

Objective: It was demonstrated that inflammation and oxidative stress induced by hyperglycemia were closely associated with alteration of miR-146a. Here, we investigated the role of miR-146a in mediating inflammation and oxidative stress in the brain of chronic T2DM rats.Methods: The chronic T2DM (c...

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Bibliographic Details
Main Authors: Yangmei Xie, Aiqun Chu, Yonghao Feng, Long Chen, Yiye Shao, Qiong Luo, Xiaolin Deng, Men Wu, Xiaohong Shi, Yinghui Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
microRNA-146a
type 2 diabetes mellitus
brain impairment
thymoquinone
inflammation
oxidative stress
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00478/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00478/full

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