Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

Cancer-associated fibroblasts (CAFs) provide critical metabolites for tumor growth and undergo metabolic reprogramming to support glycolysis. However, the molecular mechanisms responsible for this change remain unclear. Here, we report that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphor...

Full description

Bibliographic Details
Main Authors: Daoxiang Zhang, Yongbin Wang, Zhimin Shi, Jingyi Liu, Pan Sun, Xiaodan Hou, Jian Zhang, Shimin Zhao, Binhua P. Zhou, Jun Mi
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715001333

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715001333

Similar Items