Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding

The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs disc...

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Main Authors: Kathleen eMcAvoy, Antoine eBesnard, Amar eSahay
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Systems Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00120/full
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spelling doaj-3d1f7f33a4bf45b987074baf8d20e5b92020-11-24T22:38:37ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372015-08-01910.3389/fnsys.2015.00120150644Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based codingKathleen eMcAvoy0Antoine eBesnard1Amar eSahay2Center for Regenerative Medicine, Massachusetts General Hospital, Department of Psychiatry, Harvard Stem Cell Institute and Harvard Medical SchoolCenter for Regenerative Medicine, Massachusetts General Hospital, Department of Psychiatry, Harvard Stem Cell Institute and Harvard Medical SchoolCenter for Regenerative Medicine, Massachusetts General Hospital, Department of Psychiatry, Harvard Stem Cell Institute and Harvard Medical SchoolThe dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs discrimination under conditions of high, but not low, interference suggestive of a role in pattern separation. Although contextual discrimination engages population-based coding mechanisms underlying pattern separation such as global remapping in the DG and CA3, how adult hippocampal neurogenesis modulates pattern separation in the DG is poorly understood. Here, we propose a role for adult-born DGCs in re-activation coupled modulation of sparseness through feed-back inhibition to govern global remapping in the DG.http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00120/fullDentate GyrusDiscriminationinterferencePattern Separationgeneralizationadult hippocampal neurogenesis
collection DOAJ
language English
format Article
sources DOAJ
author Kathleen eMcAvoy
Antoine eBesnard
Amar eSahay
spellingShingle Kathleen eMcAvoy
Antoine eBesnard
Amar eSahay
Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
Frontiers in Systems Neuroscience
Dentate Gyrus
Discrimination
interference
Pattern Separation
generalization
adult hippocampal neurogenesis
author_facet Kathleen eMcAvoy
Antoine eBesnard
Amar eSahay
author_sort Kathleen eMcAvoy
title Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
title_short Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
title_full Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
title_fullStr Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
title_full_unstemmed Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
title_sort adult hippocampal neurogenesis and pattern separation in dg: a role for feedback inhibition in modulating sparseness to govern population-based coding
publisher Frontiers Media S.A.
series Frontiers in Systems Neuroscience
issn 1662-5137
publishDate 2015-08-01
description The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs discrimination under conditions of high, but not low, interference suggestive of a role in pattern separation. Although contextual discrimination engages population-based coding mechanisms underlying pattern separation such as global remapping in the DG and CA3, how adult hippocampal neurogenesis modulates pattern separation in the DG is poorly understood. Here, we propose a role for adult-born DGCs in re-activation coupled modulation of sparseness through feed-back inhibition to govern global remapping in the DG.
topic Dentate Gyrus
Discrimination
interference
Pattern Separation
generalization
adult hippocampal neurogenesis
url http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00120/full
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AT amaresahay adulthippocampalneurogenesisandpatternseparationindgaroleforfeedbackinhibitioninmodulatingsparsenesstogovernpopulationbasedcoding
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