Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia

Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia

A novel specific inhibitor of c-Jun N-terminal kinase, 11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one oxime sodium salt (IQ-1S), has a high affinity to JNK3 compared to JNK1/JNK2. The aim of this work was to study the mechanisms of neuroprotective activity of IQ-1S in the m...

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Bibliographic Details
Main Authors: Mark B. Plotnikov, Galina A. Chernysheva, Vera I. Smolyakova, Oleg I. Aliev, Eugene S. Trofimova, Eugene Y. Sherstoboev, Anton N. Osipenko, Andrei I. Khlebnikov, Yana J. Anfinogenova, Igor A. Schepetkin, Dmitriy N. Atochin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
neuroprotection
inhibitor of c-Jun N-terminal kinase
11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one oxime sodium salt
focal cerebral ischemia-reperfusion
Online Access:https://www.mdpi.com/2073-4409/9/8/1860

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https://www.mdpi.com/2073-4409/9/8/1860

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