A multilevel model to estimate the within- and the between-center components of the exposure/disease association in the EPIC study.

In a multicenter study, the overall relationship between exposure and the risk of cancer can be broken down into a within-center component, which reflects the individual level association, and a between-center relationship, which captures the association at the aggregate level. A piecewise exponenti...

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Bibliographic Details
Main Authors: Francesco Sera, Pietro Ferrari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4365026?pdf=render