Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber form...
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Bibliographic Details
| Main Authors: |
Anne Margarete Merks,
Marie Swinarski,
Alexander Matthias Meyer,
Nicola Victoria Müller,
Ismail Özcan,
Stefan Donat,
Alexa Burger,
Stephen Gilbert,
Christian Mosimann,
Salim Abdelilah-Seyfried,
Daniela Panáková |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04566-1
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