Synthesis and Biological Evaluation of Structurally Varied 5′-/6′-Isonucleosides and Theobromine-Containing <i>N</i>-Isonucleosidyl Derivatives

Synthesis and Biological Evaluation of Structurally Varied 5′-/6′-Isonucleosides and Theobromine-Containing <i>N</i>-Isonucleosidyl Derivatives

Isonucleosides are rather stable regioisomeric analogs of nucleosides with broad therapeutic potential. We have previously demonstrated the ability of 5&#8242; and 6&#8242;-isonucleosides to inhibit the activity of acetylcholinesterase, a major target for Alzheimer&#8217;s disease therap...

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Bibliographic Details
Main Authors: Nuno M. Xavier, Eduardo C. de Sousa, Margarida P. Pereira, Anne Loesche, Immo Serbian, René Csuk, M. Conceição Oliveira
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Pharmaceuticals
Subjects:
isonucleosides
theobromine
Mitsunobu reaction
cholinesterase inhibitors
Online Access:https://www.mdpi.com/1424-8247/12/3/103

Internet

https://www.mdpi.com/1424-8247/12/3/103

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