Acute Intestinal Inflammation Depletes/Recruits Histamine-Expressing Myeloid Cells From the Bone Marrow Leading to Exhaustion of MB-HSCsSummary

Acute Intestinal Inflammation Depletes/Recruits Histamine-Expressing Myeloid Cells From the Bone Marrow Leading to Exhaustion of MB-HSCsSummary

Background & Aims: Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. However, the role of MB-HSCs in dextran sul...

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Bibliographic Details
Main Authors: Na Fu, Feijing Wu, Zhengyu Jiang, Woosook Kim, Tuo Ruan, Ermanno Malagola, Yosuke Ochiai, Osmel Companioni Nápoles, Giovanni Valenti, Ruth A. White, Bryana R. Belin, Leah B. Zamechek, Jonathan S. LaBella, Timothy C. Wang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Histidine Decarboxylase (HDC)
Hematopoietic Stem Cell (HSC)
Myeloid Cell
Intestine Inflammation
H2-Receptor (H2R) Agonist
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301867

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http://www.sciencedirect.com/science/article/pii/S2352345X20301867

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