Vascularized Microfluidics and the Blood–Endothelium Interface
The microvasculature is the primary conduit through which the human body transmits oxygen, nutrients, and other biological information to its peripheral tissues. It does this through bidirectional communication between the blood, consisting of plasma and non-adherent cells, and the microvascular end...
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doaj-3ef678e36d2149a5bc86c9134847eb0f2020-11-25T01:15:22ZengMDPI AGMicromachines2072-666X2019-12-011111810.3390/mi11010018mi11010018Vascularized Microfluidics and the Blood–Endothelium InterfaceChristopher A. Hesh0Yongzhi Qiu1Wilbur A. Lam2Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USAWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USAThe microvasculature is the primary conduit through which the human body transmits oxygen, nutrients, and other biological information to its peripheral tissues. It does this through bidirectional communication between the blood, consisting of plasma and non-adherent cells, and the microvascular endothelium. Current understanding of this blood−endothelium interface has been predominantly derived from a combination of reductionist two-dimensional in vitro models and biologically complex in vivo animal models, both of which recapitulate the human microvasculature to varying but limited degrees. In an effort to address these limitations, vascularized microfluidics have become a platform of increasing importance as a consequence of their ability to isolate biologically complex phenomena while also recapitulating biochemical and biophysical behaviors known to be important to the function of the blood−endothelium interface. In this review, we discuss the basic principles of vascularized microfluidic fabrication, the contribution this platform has made to our understanding of the blood−endothelium interface in both homeostasis and disease, the limitations and challenges of these vascularized microfluidics for studying this interface, and how these inform future directions.https://www.mdpi.com/2072-666X/11/1/18blood vesselmicrovasculatureendotheliumlab-on-chipmicrofluidics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christopher A. Hesh Yongzhi Qiu Wilbur A. Lam |
spellingShingle |
Christopher A. Hesh Yongzhi Qiu Wilbur A. Lam Vascularized Microfluidics and the Blood–Endothelium Interface Micromachines blood vessel microvasculature endothelium lab-on-chip microfluidics |
author_facet |
Christopher A. Hesh Yongzhi Qiu Wilbur A. Lam |
author_sort |
Christopher A. Hesh |
title |
Vascularized Microfluidics and the Blood–Endothelium Interface |
title_short |
Vascularized Microfluidics and the Blood–Endothelium Interface |
title_full |
Vascularized Microfluidics and the Blood–Endothelium Interface |
title_fullStr |
Vascularized Microfluidics and the Blood–Endothelium Interface |
title_full_unstemmed |
Vascularized Microfluidics and the Blood–Endothelium Interface |
title_sort |
vascularized microfluidics and the blood–endothelium interface |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2019-12-01 |
description |
The microvasculature is the primary conduit through which the human body transmits oxygen, nutrients, and other biological information to its peripheral tissues. It does this through bidirectional communication between the blood, consisting of plasma and non-adherent cells, and the microvascular endothelium. Current understanding of this blood−endothelium interface has been predominantly derived from a combination of reductionist two-dimensional in vitro models and biologically complex in vivo animal models, both of which recapitulate the human microvasculature to varying but limited degrees. In an effort to address these limitations, vascularized microfluidics have become a platform of increasing importance as a consequence of their ability to isolate biologically complex phenomena while also recapitulating biochemical and biophysical behaviors known to be important to the function of the blood−endothelium interface. In this review, we discuss the basic principles of vascularized microfluidic fabrication, the contribution this platform has made to our understanding of the blood−endothelium interface in both homeostasis and disease, the limitations and challenges of these vascularized microfluidics for studying this interface, and how these inform future directions. |
topic |
blood vessel microvasculature endothelium lab-on-chip microfluidics |
url |
https://www.mdpi.com/2072-666X/11/1/18 |
work_keys_str_mv |
AT christopherahesh vascularizedmicrofluidicsandthebloodendotheliuminterface AT yongzhiqiu vascularizedmicrofluidicsandthebloodendotheliuminterface AT wilburalam vascularizedmicrofluidicsandthebloodendotheliuminterface |
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