Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women

Objective: To evaluate the relationship between maternal serum levels of pregnancy-associated-plasma-protein-A (PAPP-A) and β-human-chorionic-gonadotropin (β-hCG) and pregnancy complications. Materials and methods: This is a case-control study conducted during 2015- 2016. Women at their first pregn...

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Main Authors: Hatav Ghasemi Tehrani, Arezoo Sadeghian, Reza Entezari
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-06-01
Series:Journal of Family and Reproductive Health
Subjects:
Online Access:https://jfrh.tums.ac.ir/index.php/jfrh/article/view/654
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spelling doaj-3efba57ed1ff4b5d8109c37b493a5e342021-04-02T12:19:59ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922018-06-01114403Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian WomenHatav Ghasemi Tehrani0Arezoo Sadeghian1Reza Entezari2Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudents’ Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudents’ Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranObjective: To evaluate the relationship between maternal serum levels of pregnancy-associated-plasma-protein-A (PAPP-A) and β-human-chorionic-gonadotropin (β-hCG) and pregnancy complications. Materials and methods: This is a case-control study conducted during 2015- 2016. Women at their first pregnancy were enrolled and serum PAPP-A and free-β-hCG were measured in 9-14 weeks of gestation. They were followed till the end of pregnancylooking for complications including preterm labor, pregnancy induced hypertension (PIH), abortion, and intra-uterine growth retardation (IUGR). Results: A total of 1070 pregnant women (mean age: 28.64 ± 4.95 years) were enrolled. Low serum levels of PAPP-A were more frequent in patients developing IUGR (17.4% versus 1.2%, p < 0.001), preterm labor (13% versus 2%, p = 0.013), and PIH (17.4% versus 4%, p = 0.015) compared those without complications. The serum levels of free-β-hCG were not different in patients with and without complications (p > 0.05). Conclusion: There is an association between low serum levels of PAPP-A and developing IUGR, preterm labor, and PIH.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/654β-hCGComplicationsFirst trimesterPAPP-APregnancy
collection DOAJ
language English
format Article
sources DOAJ
author Hatav Ghasemi Tehrani
Arezoo Sadeghian
Reza Entezari
spellingShingle Hatav Ghasemi Tehrani
Arezoo Sadeghian
Reza Entezari
Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
Journal of Family and Reproductive Health
β-hCG
Complications
First trimester
PAPP-A
Pregnancy
author_facet Hatav Ghasemi Tehrani
Arezoo Sadeghian
Reza Entezari
author_sort Hatav Ghasemi Tehrani
title Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
title_short Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
title_full Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
title_fullStr Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
title_full_unstemmed Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
title_sort relationship between pregnancy complications and serum pregnancy associated-plasma-protein-a and free-β-human chorionic gonadotropin in the first trimester among iranian women
publisher Tehran University of Medical Sciences
series Journal of Family and Reproductive Health
issn 1735-8949
1735-9392
publishDate 2018-06-01
description Objective: To evaluate the relationship between maternal serum levels of pregnancy-associated-plasma-protein-A (PAPP-A) and β-human-chorionic-gonadotropin (β-hCG) and pregnancy complications. Materials and methods: This is a case-control study conducted during 2015- 2016. Women at their first pregnancy were enrolled and serum PAPP-A and free-β-hCG were measured in 9-14 weeks of gestation. They were followed till the end of pregnancylooking for complications including preterm labor, pregnancy induced hypertension (PIH), abortion, and intra-uterine growth retardation (IUGR). Results: A total of 1070 pregnant women (mean age: 28.64 ± 4.95 years) were enrolled. Low serum levels of PAPP-A were more frequent in patients developing IUGR (17.4% versus 1.2%, p < 0.001), preterm labor (13% versus 2%, p = 0.013), and PIH (17.4% versus 4%, p = 0.015) compared those without complications. The serum levels of free-β-hCG were not different in patients with and without complications (p > 0.05). Conclusion: There is an association between low serum levels of PAPP-A and developing IUGR, preterm labor, and PIH.
topic β-hCG
Complications
First trimester
PAPP-A
Pregnancy
url https://jfrh.tums.ac.ir/index.php/jfrh/article/view/654
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