Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women
Objective: To evaluate the relationship between maternal serum levels of pregnancy-associated-plasma-protein-A (PAPP-A) and β-human-chorionic-gonadotropin (β-hCG) and pregnancy complications. Materials and methods: This is a case-control study conducted during 2015- 2016. Women at their first pregn...
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Tehran University of Medical Sciences
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doaj-3efba57ed1ff4b5d8109c37b493a5e342021-04-02T12:19:59ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922018-06-01114403Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian WomenHatav Ghasemi Tehrani0Arezoo Sadeghian1Reza Entezari2Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudents’ Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudents’ Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranObjective: To evaluate the relationship between maternal serum levels of pregnancy-associated-plasma-protein-A (PAPP-A) and β-human-chorionic-gonadotropin (β-hCG) and pregnancy complications. Materials and methods: This is a case-control study conducted during 2015- 2016. Women at their first pregnancy were enrolled and serum PAPP-A and free-β-hCG were measured in 9-14 weeks of gestation. They were followed till the end of pregnancylooking for complications including preterm labor, pregnancy induced hypertension (PIH), abortion, and intra-uterine growth retardation (IUGR). Results: A total of 1070 pregnant women (mean age: 28.64 ± 4.95 years) were enrolled. Low serum levels of PAPP-A were more frequent in patients developing IUGR (17.4% versus 1.2%, p < 0.001), preterm labor (13% versus 2%, p = 0.013), and PIH (17.4% versus 4%, p = 0.015) compared those without complications. The serum levels of free-β-hCG were not different in patients with and without complications (p > 0.05). Conclusion: There is an association between low serum levels of PAPP-A and developing IUGR, preterm labor, and PIH.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/654β-hCGComplicationsFirst trimesterPAPP-APregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hatav Ghasemi Tehrani Arezoo Sadeghian Reza Entezari |
spellingShingle |
Hatav Ghasemi Tehrani Arezoo Sadeghian Reza Entezari Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women Journal of Family and Reproductive Health β-hCG Complications First trimester PAPP-A Pregnancy |
author_facet |
Hatav Ghasemi Tehrani Arezoo Sadeghian Reza Entezari |
author_sort |
Hatav Ghasemi Tehrani |
title |
Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women |
title_short |
Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women |
title_full |
Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women |
title_fullStr |
Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women |
title_full_unstemmed |
Relationship Between Pregnancy Complications and Serum Pregnancy Associated-Plasma-Protein-A and Free-β-Human Chorionic Gonadotropin in the First Trimester Among Iranian Women |
title_sort |
relationship between pregnancy complications and serum pregnancy associated-plasma-protein-a and free-β-human chorionic gonadotropin in the first trimester among iranian women |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Family and Reproductive Health |
issn |
1735-8949 1735-9392 |
publishDate |
2018-06-01 |
description |
Objective: To evaluate the relationship between maternal serum levels of pregnancy-associated-plasma-protein-A (PAPP-A) and β-human-chorionic-gonadotropin (β-hCG) and pregnancy complications.
Materials and methods: This is a case-control study conducted during 2015- 2016. Women at their first pregnancy were enrolled and serum PAPP-A and free-β-hCG were measured in 9-14 weeks of gestation. They were followed till the end of pregnancylooking for complications including preterm labor, pregnancy induced hypertension (PIH), abortion, and intra-uterine growth retardation (IUGR).
Results: A total of 1070 pregnant women (mean age: 28.64 ± 4.95 years) were enrolled. Low serum levels of PAPP-A were more frequent in patients developing IUGR (17.4% versus 1.2%, p < 0.001), preterm labor (13% versus 2%, p = 0.013), and PIH (17.4% versus 4%, p = 0.015) compared those without complications. The serum levels of free-β-hCG were not different in patients with and without complications (p > 0.05).
Conclusion: There is an association between low serum levels of PAPP-A and developing IUGR, preterm labor, and PIH. |
topic |
β-hCG Complications First trimester PAPP-A Pregnancy |
url |
https://jfrh.tums.ac.ir/index.php/jfrh/article/view/654 |
work_keys_str_mv |
AT hatavghasemitehrani relationshipbetweenpregnancycomplicationsandserumpregnancyassociatedplasmaproteinaandfreebhumanchorionicgonadotropininthefirsttrimesteramongiranianwomen AT arezoosadeghian relationshipbetweenpregnancycomplicationsandserumpregnancyassociatedplasmaproteinaandfreebhumanchorionicgonadotropininthefirsttrimesteramongiranianwomen AT rezaentezari relationshipbetweenpregnancycomplicationsandserumpregnancyassociatedplasmaproteinaandfreebhumanchorionicgonadotropininthefirsttrimesteramongiranianwomen |
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