Loss of Bin1 Promotes the Propagation of Tau Pathology

Loss of Bin1 Promotes the Propagation of Tau Pathology

Tau pathology propagates within synaptically connected neuronal circuits, but the underlying mechanisms are unclear. BIN1-amphiphysin2 is the second most prevalent genetic risk factor for late-onset Alzheimer’s disease. In diseased brains, the BIN1-amphiphysin2 neuronal isoform is downregulated. Her...

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Bibliographic Details
Main Authors: Sara Calafate, William Flavin, Patrik Verstreken, Diederik Moechars
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
Tau
spreading
in vitro model
BIN1
Alzheimer GWAS
synapse
endocytosis
Rab5
galectin-3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313195

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http://www.sciencedirect.com/science/article/pii/S2211124716313195

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