Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region

Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region

Objectives: Between-person variability in T-cell-specific interferon-gamma release assay (IGRA) responses and discordance between IGRA test formats are poorly understood. Methods: We evaluated the IFN-γ responses (QuantiFERON-TB Gold-In-Tube [QFT-GIT] and TSPOT-TB) stratified according to the Mycoba...

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Bibliographic Details
Main Authors: Michele Tomasicchio, Jason Limberis, Ruben van der Merwe, Rachael Jacobson, Richard Meldau, Grant Theron, Mark Nicol, Rob Warren, Keertan Dheda
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:International Journal of Infectious Diseases
Subjects:
Mycobacterium tuberculosis
Interferon-gamma release assay
Host immune response
Strain
Online Access:http://www.sciencedirect.com/science/article/pii/S120197122030268X

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http://www.sciencedirect.com/science/article/pii/S120197122030268X

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