Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella

Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella

Abstract Objective There are no vaccines for most of the major invasive Salmonella strains causing severe infection in humans. We evaluated the specificity of adaptive T memory cell responses generated after Salmonella Typhi exposure in humans against other major invasive Salmonella strains sharing...

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Bibliographic Details
Main Authors: Rekha R Rapaka, Rezwanul Wahid, Stephanie Fresnay, Jayaum S Booth, Thomas C Darton, Claire Jones, Claire S Waddington, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
human challenge
iNTS
invasive Salmonella
Paratyphi
S. Typhi
T‐cell memory
Online Access:https://doi.org/10.1002/cti2.1178

Internet

https://doi.org/10.1002/cti2.1178

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