Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor

TRPM8 (transient receptor potential M8) and TRPA1 (transient receptor potential A1) are cold-temperature-sensitive nociceptors expressed in sensory neurons but their behaviour in neuronal cells is poorly understood. Therefore DNA expression constructs containing human TRPM8 or TRPA1 cDNAs were tran...

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Bibliographic Details
Main Authors: Kevin Morgan, Laura R. Sadofsky, Christopher Crow, Alyn H. Morice
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-08-01
Series:Bioscience Reports
Subjects:
EC50
SNP
TRPA1
TRPM8
tyrosine kinases
Online Access:http://www.bioscirep.org/bsr/034/e131/bsr034e131.htm

Internet

http://www.bioscirep.org/bsr/034/e131/bsr034e131.htm

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