Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego
Isoflavones are members of flavonoids which belong to phytoestrogens, a group of non-steroid plant substancesthe chemical structure of which is similar to 17-β-estradiol. One of the richest sources of isoflavones issoybeans and legumes. The most important representatives of this class of compounds w...
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doaj-408e0653cc6b417ab5f2fe93bb36bf4e2020-11-24T23:05:54ZengTermedia Publishing HouseMenopause Review1643-88762010-12-01146402406Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnegoMichał BijakIreneusz PołaćMarta BorowieckaPaweł NowakTomasz StetkiewiczTomasz PertyńskiIsoflavones are members of flavonoids which belong to phytoestrogens, a group of non-steroid plant substancesthe chemical structure of which is similar to 17-β-estradiol. One of the richest sources of isoflavones issoybeans and legumes. The most important representatives of this class of compounds which have biologicalactivity are daidzein and genistein. Isoflavones are able to bind to estrogen receptors (ER) however, their affinityto ER-β is higher than ER-α. Interaction isoflavones with ER lead to their activation. which causes cell response.The last epidemiological studies provide evidence that in Asia where soya is present in the traditional diet,women have less negative symptoms of menopause compared with the Western population. Clinical studiescarried out in recent years have shown that soy protein or genistein supplementation reduces the number ofhot flushes in post menopausal women. Similar results are shown for bone health. Genistein supplementationcauses an increase in bone mineral density (BMD) and decrease in levels of bone resorption markers at a levelcomparable to hormone therapy. Isoflavones have also positive effects on the cardiovascular system. For allthese reasons isoflavones are becoming an increasingly popular and safe alternative to hormone therapy forwomen with menopausal symptoms. This article describes the structure and metabolism of isoflavones as wellas mechanism of action and results of clinical studies in postmenopausal women receiving isoflavones.http://www.termedia.pl/Izoflawony-jako-alternatywa-dla-terapii-hormonalnej-wieku-enopauzalnego,4,15866,1,0.htmlisoflavonesphytoestrogenshormone therapymenopause |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michał Bijak Ireneusz Połać Marta Borowiecka Paweł Nowak Tomasz Stetkiewicz Tomasz Pertyński |
spellingShingle |
Michał Bijak Ireneusz Połać Marta Borowiecka Paweł Nowak Tomasz Stetkiewicz Tomasz Pertyński Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego Menopause Review isoflavones phytoestrogens hormone therapy menopause |
author_facet |
Michał Bijak Ireneusz Połać Marta Borowiecka Paweł Nowak Tomasz Stetkiewicz Tomasz Pertyński |
author_sort |
Michał Bijak |
title |
Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego |
title_short |
Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego |
title_full |
Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego |
title_fullStr |
Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego |
title_full_unstemmed |
Izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego |
title_sort |
izoflawony jako alternatywa dla terapii hormonalnej wieku menopauzalnego |
publisher |
Termedia Publishing House |
series |
Menopause Review |
issn |
1643-8876 |
publishDate |
2010-12-01 |
description |
Isoflavones are members of flavonoids which belong to phytoestrogens, a group of non-steroid plant substancesthe chemical structure of which is similar to 17-β-estradiol. One of the richest sources of isoflavones issoybeans and legumes. The most important representatives of this class of compounds which have biologicalactivity are daidzein and genistein. Isoflavones are able to bind to estrogen receptors (ER) however, their affinityto ER-β is higher than ER-α. Interaction isoflavones with ER lead to their activation. which causes cell response.The last epidemiological studies provide evidence that in Asia where soya is present in the traditional diet,women have less negative symptoms of menopause compared with the Western population. Clinical studiescarried out in recent years have shown that soy protein or genistein supplementation reduces the number ofhot flushes in post menopausal women. Similar results are shown for bone health. Genistein supplementationcauses an increase in bone mineral density (BMD) and decrease in levels of bone resorption markers at a levelcomparable to hormone therapy. Isoflavones have also positive effects on the cardiovascular system. For allthese reasons isoflavones are becoming an increasingly popular and safe alternative to hormone therapy forwomen with menopausal symptoms. This article describes the structure and metabolism of isoflavones as wellas mechanism of action and results of clinical studies in postmenopausal women receiving isoflavones. |
topic |
isoflavones phytoestrogens hormone therapy menopause |
url |
http://www.termedia.pl/Izoflawony-jako-alternatywa-dla-terapii-hormonalnej-wieku-enopauzalnego,4,15866,1,0.html |
work_keys_str_mv |
AT michałbijak izoflawonyjakoalternatywadlaterapiihormonalnejwiekumenopauzalnego AT ireneuszpołac izoflawonyjakoalternatywadlaterapiihormonalnejwiekumenopauzalnego AT martaborowiecka izoflawonyjakoalternatywadlaterapiihormonalnejwiekumenopauzalnego AT pawełnowak izoflawonyjakoalternatywadlaterapiihormonalnejwiekumenopauzalnego AT tomaszstetkiewicz izoflawonyjakoalternatywadlaterapiihormonalnejwiekumenopauzalnego AT tomaszpertynski izoflawonyjakoalternatywadlaterapiihormonalnejwiekumenopauzalnego |
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1725624996507680768 |