Effect of VH–VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding

Effect of VH–VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding

Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure. With seven known VH families, and up to six known κ VL families, there are choices aplenty. However, the functions of these...

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Bibliographic Details
Main Authors: Wei-Li Ling, Wai-Heng Lua, Jun-Jie Poh, Joshua Yi Yeo, David Philip Lane, Samuel Ken-En Gan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
complementary determining region grafting
FcγIIA
KD
Pertuzumab
recombinant antibody production
Trastuzumab
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00469/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00469/full

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