LC-MS/MS assay for the simultaneous quantitation of thromboxane B2 and prostaglandin E2 to evaluate cyclooxygenase inhibition in human whole blood
OBJECTIVES: A high-throughput LC-MS method for TXB2 and PGE2 was developed for human whole blood assay for COX inhibition. METHODS: A surrogate analyte approach was used for the quantitation of TXB2 and PGE2 by LC-MS. Fifty microliters plasma was processed using solid-phase extraction. TXB2-d4 an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Betasciencepress Publishers
2020-08-01
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| Series: | Journal of Applied Bioanalysis |
| Subjects: | |
| Online Access: | https://doi.org/10.17145/jab.20.014 |