Rats fed linseed oil in microemulsion forms enriches the cardiac sarcoplasmic reticulum lipids with docosahexaenoic acid and lower calcium transport

• Main Authors: D. Sugasini, B.R. Lokesh
• Format: Article
• Language: English
• Published: Elsevier 2013-10-01
• Series: Journal of Functional Foods
• Subjects: Alpha linolenic acid; Docosahexaenoic acid; Microemulsions; Sarcoplasmic reticulum; Ca2+Mg2+ ATPase; Ca2+ transport
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464613002065

The effect of feeding rats with whey protein or lipoid microemulsion of n-3 rich linseed oil (LSO), and n-6 rich sunflower oil (SNO) compared to native or microemulsion forms of each oil for 60 days on fatty acid composition, Ca2+Mg2+ ATPase, Ca2+ uptake and membrane fluidity of rat cardiac sarcoplasmic reticulum (SR) were assessed. Rats consuming LSO in lipoid microemulsion showed higher levels of ALA (18:3, n-3) conversion to DHA (22:6, n-3) when compared to rats given LSO in native form. Compared to all other dietary treatments, the alterations in the n-6/n-3 PUFA composition of SR of rats given LSO in lipoid microemulsion effected the greatest changes in Ca2+Mg2+ ATPase activity and Ca2+ uptake which effectively reduced Ca2+ transport. Therefore, the LSO in lipoid microemulsion confers similar heart healthy fatty acid compositional and calcium transport changes and potentially anti-arrhythmic effects similar to fish oils.