Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Abstract Background Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysical traits presented by an individual antigen of int...

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Bibliographic Details
Main Authors: Neil C. Dalvie, Joseph R. Brady, Laura E. Crowell, Mary Kate Tracey, Andrew M. Biedermann, Kawaljit Kaur, John M. Hickey, D. Lee Kristensen, Alexandra D. Bonnyman, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Marina Bok, Celina Vega, Tarit K. Mukhopadhyay, Sangeeta B. Joshi, David B. Volkin, Viviana Parreño, Kerry R. Love, J. Christopher Love
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Microbial Cell Factories
Subjects:
Pichia pastoris
Subunit vaccine
Quality by design
Biomanufacturing
Online Access:https://doi.org/10.1186/s12934-021-01583-6

Internet

https://doi.org/10.1186/s12934-021-01583-6

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