Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas
Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates short segments of foreign genetic material (spacers) into the CRISPR locus. It is hypothesized that Cas1 evolved from casposases, a novel cla...
Main Authors: | Alison B Hickman, Shweta Kailasan, Pavol Genzor, Astrid D Haase, Fred Dyda |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-01-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/50004 |
Similar Items
-
The CARF Protein MM_0565 Affects Transcription of the Casposon-Encoded <i>cas1-solo</i> Gene in <i>Methanosarcina mazei</i> Gö1
by: Andrea Ulbricht, et al.
Published: (2020-08-01) -
Anti‐CRISPRs: The natural inhibitors for CRISPR‐Cas systems
by: Fei Zhang, et al.
Published: (2019-06-01) -
Cas1 and Cas2 From the Type II-C CRISPR-Cas System of Riemerella anatipestifer Are Required for Spacer Acquisition
by: Yang He, et al.
Published: (2018-06-01) -
Insights into the Human Virome Using CRISPR Spacers from Microbiomes
by: Claudio Hidalgo-Cantabrana, et al.
Published: (2018-09-01) -
Bioinformational analysis of Yersinia pseudotuberculosis IP32953 CRISPR/cas system
by: N. P. Peretolchina, et al.
Published: (2016-09-01)