D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels

D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels

Astrocytes are involved in chemoreception in brainstem areas that regulate breathing rhythm, and astrocytes are known to release d-serine. Here the authors show that astrocyte release of d-serine contributes to CO2 sensing and breathing in brainstem slices, and in vivo in awake unrestrained mice.

Bibliographic Details
Main Authors: S. Beltrán-Castillo, M. J. Olivares, R. A. Contreras, G. Zúñiga, I. Llona, R. von Bernhardi, J. L. Eugenín
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00960-3
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spelling doaj-41b84a8ca1b3417ea545aec89f9708182021-05-11T07:54:19ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-00960-3D-serine released by astrocytes in brainstem regulates breathing response to CO2 levelsS. Beltrán-Castillo0M. J. Olivares1R. A. Contreras2G. Zúñiga3I. Llona4R. von Bernhardi5J. L. Eugenín6Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACHDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACHDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACHDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACHDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACHDepartamento de Neurología, Facultad de Medicina, Pontificia Universidad Católica de ChileDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACHAstrocytes are involved in chemoreception in brainstem areas that regulate breathing rhythm, and astrocytes are known to release d-serine. Here the authors show that astrocyte release of d-serine contributes to CO2 sensing and breathing in brainstem slices, and in vivo in awake unrestrained mice.https://doi.org/10.1038/s41467-017-00960-3
collection DOAJ
language English
format Article
sources DOAJ
author S. Beltrán-Castillo
M. J. Olivares
R. A. Contreras
G. Zúñiga
I. Llona
R. von Bernhardi
J. L. Eugenín
spellingShingle S. Beltrán-Castillo
M. J. Olivares
R. A. Contreras
G. Zúñiga
I. Llona
R. von Bernhardi
J. L. Eugenín
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Nature Communications
author_facet S. Beltrán-Castillo
M. J. Olivares
R. A. Contreras
G. Zúñiga
I. Llona
R. von Bernhardi
J. L. Eugenín
author_sort S. Beltrán-Castillo
title D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
title_short D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
title_full D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
title_fullStr D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
title_full_unstemmed D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
title_sort d-serine released by astrocytes in brainstem regulates breathing response to co2 levels
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Astrocytes are involved in chemoreception in brainstem areas that regulate breathing rhythm, and astrocytes are known to release d-serine. Here the authors show that astrocyte release of d-serine contributes to CO2 sensing and breathing in brainstem slices, and in vivo in awake unrestrained mice.
url https://doi.org/10.1038/s41467-017-00960-3
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AT racontreras dserinereleasedbyastrocytesinbrainstemregulatesbreathingresponsetoco2levels
AT gzuniga dserinereleasedbyastrocytesinbrainstemregulatesbreathingresponsetoco2levels
AT illona dserinereleasedbyastrocytesinbrainstemregulatesbreathingresponsetoco2levels
AT rvonbernhardi dserinereleasedbyastrocytesinbrainstemregulatesbreathingresponsetoco2levels
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