Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis

Background: The utility of QuantiFERON-TB Gold In-Tube (QFT-G) test in the diagnosis of tuberculosis disease has been validated in high and low tuberculosis-prevalent (TB) countries. Aim: The aim of this study is to assess the performance of the QFT-G test in the diagnosis of tuberculosis disease am...

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Main Authors: Ahmed Anwar, AL-Jahdali Hamdan, Baharoon Salim, Ali Yosra, Mohamed Hani, AL-Harbi Abdullah
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Journal of Global Infectious Diseases
Subjects:
Online Access:http://www.jgid.org/article.asp?issn=0974-777X;year=2015;volume=7;issue=3;spage=108;epage=112;aulast=Anwar
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spelling doaj-41c9c6e71f244784a24244bd1615ec9c2020-11-25T00:02:05ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X2015-01-017310811210.4103/0974-777X.162231Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosisAhmed AnwarAL-Jahdali HamdanBaharoon SalimAli YosraMohamed HaniAL-Harbi AbdullahBackground: The utility of QuantiFERON-TB Gold In-Tube (QFT-G) test in the diagnosis of tuberculosis disease has been validated in high and low tuberculosis-prevalent (TB) countries. Aim: The aim of this study is to assess the performance of the QFT-G test in the diagnosis of tuberculosis disease among tuberculosis patients in an intermediate prevalent country. Setting and Design: A retrospective study at the King Abdulaziz Medical City-Riyadh (KAMC-R) Materials and Methods: We retrospectively reviewed all the patients with a diagnosis of pneumonia, including tuberculosis, admitted to KAMC-R between 1 January 2009 and 31 December 2013. We included only patients with an available result of the QFT-G test. A total of 142 tuberculosis cases and 226 pneumonia cases were studied, to assess the utility of the QFT-G test in diagnosing tuberculosis cases. Results: Among the tuberculosis (n = 142) cases, the QFT-G tested positive in 68.3%, negative in 23.2%, and indeterminate in 12 cases (8.5%). Of the 226 pneumonia cases, the QFT-G tested positive in only 20.4%, while a majority of 66.4% tested negative, with 30 cases (13.3%) being indeterminate. When we excluded 42 patients with indeterminate results, the QFT-G test achieved a sensitivity of 74.6% [95% CI: 66.09 to 81.65%] and specificity of 76.53 % [95% CI: 69.85 to 82.15%] in the diagnosis of tuberculosis cases. Conclusions: This study concludes that the QFT-G test is a useful tool for detecting tuberculosis disease when used as an adjunct tool for the diagnosis of active TB cases. It certainly cannot be used solely and indiscriminately, separate from other clinical and radiological information, in the diagnosis of active tuberculosis cases.http://www.jgid.org/article.asp?issn=0974-777X;year=2015;volume=7;issue=3;spage=108;epage=112;aulast=AnwarPneumoniaQuantiFERONQFT-GTuberculosis
collection DOAJ
language English
format Article
sources DOAJ
author Ahmed Anwar
AL-Jahdali Hamdan
Baharoon Salim
Ali Yosra
Mohamed Hani
AL-Harbi Abdullah
spellingShingle Ahmed Anwar
AL-Jahdali Hamdan
Baharoon Salim
Ali Yosra
Mohamed Hani
AL-Harbi Abdullah
Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis
Journal of Global Infectious Diseases
Pneumonia
QuantiFERON
QFT-G
Tuberculosis
author_facet Ahmed Anwar
AL-Jahdali Hamdan
Baharoon Salim
Ali Yosra
Mohamed Hani
AL-Harbi Abdullah
author_sort Ahmed Anwar
title Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis
title_short Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis
title_full Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis
title_fullStr Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis
title_full_unstemmed Diagnostic utility of QuantiFERON-TB gold (QFT-G) in active pulmonary tuberculosis
title_sort diagnostic utility of quantiferon-tb gold (qft-g) in active pulmonary tuberculosis
publisher Wolters Kluwer Medknow Publications
series Journal of Global Infectious Diseases
issn 0974-777X
publishDate 2015-01-01
description Background: The utility of QuantiFERON-TB Gold In-Tube (QFT-G) test in the diagnosis of tuberculosis disease has been validated in high and low tuberculosis-prevalent (TB) countries. Aim: The aim of this study is to assess the performance of the QFT-G test in the diagnosis of tuberculosis disease among tuberculosis patients in an intermediate prevalent country. Setting and Design: A retrospective study at the King Abdulaziz Medical City-Riyadh (KAMC-R) Materials and Methods: We retrospectively reviewed all the patients with a diagnosis of pneumonia, including tuberculosis, admitted to KAMC-R between 1 January 2009 and 31 December 2013. We included only patients with an available result of the QFT-G test. A total of 142 tuberculosis cases and 226 pneumonia cases were studied, to assess the utility of the QFT-G test in diagnosing tuberculosis cases. Results: Among the tuberculosis (n = 142) cases, the QFT-G tested positive in 68.3%, negative in 23.2%, and indeterminate in 12 cases (8.5%). Of the 226 pneumonia cases, the QFT-G tested positive in only 20.4%, while a majority of 66.4% tested negative, with 30 cases (13.3%) being indeterminate. When we excluded 42 patients with indeterminate results, the QFT-G test achieved a sensitivity of 74.6% [95% CI: 66.09 to 81.65%] and specificity of 76.53 % [95% CI: 69.85 to 82.15%] in the diagnosis of tuberculosis cases. Conclusions: This study concludes that the QFT-G test is a useful tool for detecting tuberculosis disease when used as an adjunct tool for the diagnosis of active TB cases. It certainly cannot be used solely and indiscriminately, separate from other clinical and radiological information, in the diagnosis of active tuberculosis cases.
topic Pneumonia
QuantiFERON
QFT-G
Tuberculosis
url http://www.jgid.org/article.asp?issn=0974-777X;year=2015;volume=7;issue=3;spage=108;epage=112;aulast=Anwar
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