Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both...

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Bibliographic Details
Main Authors: Xueya Zhou, Ching-Lung Cheung, Tatsuki Karasugi, Jaro Karppinen, Dino Samartzis, Yi-Hsiang Hsu, Timothy Shin-Heng Mak, You-Qiang Song, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yan Li, Danny Chan, Kenneth Man-Chee Cheung, Shiro Ikegawa, Kathryn Song-Eng Cheah, Pak Chung Sham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Genetics
Subjects:
polygenic score
genetic correlation
causality
pleiotropy
lumbar disc degeneration
osteoarthritis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00267/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00267/full

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