Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice.

The lung changes functionally and structurally with aging. However, age-related effects on the extracellular matrix (ECM) and corresponding effects on lung cell behavior are not well understood. We hypothesized that ECM from aged animals would induce aging-related phenotypic changes in healthy inocu...

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Bibliographic Details
Main Authors: Lindsay M Godin, Brian J Sandri, Darcy E Wagner, Carolyn M Meyer, Andrew P Price, Ifeolu Akinnola, Daniel J Weiss, Angela Panoskaltsis-Mortari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4783067?pdf=render