Effects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of sphingosine (SPN) and ceramide analogues on phorbol 12-myristate 13-acetate (PMA, 5 × 10-7M) sti...

Full description

Bibliographic Details
Main Authors: A. Mouithys-Mickalad, G. Deby-Dupont, M. Hoebeke, M. Mathy-Hartert, M. Lamy, C. Deby
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629359791460