Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Abstract Background High-dose intravenous vitamin C directly scavenges and decreases the production of harmful reactive oxygen species (ROS) generated during ischemia/reperfusion after a cardiac arrest. The aim of this study is to investigate whether short-term treatment with a supplementary or very...

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Bibliographic Details
Main Authors: Sander Rozemeijer, Harm-Jan de Grooth, Paul W. G. Elbers, Armand R. J. Girbes, Corstiaan A. den Uil, Eric A. Dubois, Evert-Jan Wils, Thijs C. D. Rettig, Arthur R. H. van Zanten, Roel Vink, Bas van den Bogaard, Rob J. Bosman, Heleen M. Oudemans-van Straaten, Angélique M. E. de Man
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Trials
Subjects:
Out-of-hospital cardiac arrest
Ischemia/reperfusion injury
Post-cardiac arrest syndrome
Cardiac arrest
Free radicals
Reactive oxygen species
Online Access:https://doi.org/10.1186/s13063-021-05483-3

Internet

https://doi.org/10.1186/s13063-021-05483-3

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