Physiological Roles of DNA Double-Strand Breaks
Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. Cells boast a considerable set of defences to both prevent and r...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
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Series: | Journal of Nucleic Acids |
Online Access: | http://dx.doi.org/10.1155/2017/6439169 |