Physiological Roles of DNA Double-Strand Breaks

Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. Cells boast a considerable set of defences to both prevent and r...

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Bibliographic Details
Main Authors: Farhaan A. Khan, Syed O. Ali
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.1155/2017/6439169