Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition

Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition

Although integrin alpha 2 subunit (ITGA2) mediates cancer progression and metastasis, its transfer by exosomes has not been investigated in prostate cancer (PCa). We aimed to determine the role of exosomal ITGA2 derived from castration-resistant PCa (CRPC) cells in promoting aggressive phenotypes in...

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Bibliographic Details
Main Authors: Rofaida Gaballa, Hamdy E. A. Ali, Mohamed O. Mahmoud, Johng S. Rhim, Hamed I. Ali, Heba F. Salem, Mohammad Saleem, Mohamed A. Kandeil, Stefan Ambs, Zakaria Y. Abd Elmageed
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
prostate cancer
CRPC
exosomes
ITGA2
metastasis
EMT
Online Access:https://www.mdpi.com/2072-6694/12/8/2300

Internet

https://www.mdpi.com/2072-6694/12/8/2300

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