Succinate Dehydrogenase B Subunit Immunohistochemical Expression Predicts Aggressiveness in Well Differentiated Neuroendocrine Tumors of the Ileum

Immunohistochemical loss of the succinate dehydrogenase subunit B (SDHB) has recently been reported as a surrogate biomarker of malignancy in sporadic and familial pheocromocytomas and paragangliomas through the activation of hypoxia pathways. However, data on the prevalence and the clinical implica...

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Bibliographic Details
Main Authors: Filippo G. de Braud, Giuseppe Pelosi, Vincenzo Mazzaferro, Patrick Maisonneuve, Flavia Melotti, Patrizia Gasparini, Massimo Milione, Sara Pusceddu
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/4/3/808