Hematologists’ barriers and enablers to screening and recruiting patients to a chimeric antigen receptor (CAR) T cell therapy trial: a theory-informed interview study

Hematologists’ barriers and enablers to screening and recruiting patients to a chimeric antigen receptor (CAR) T cell therapy trial: a theory-informed interview study

Abstract Background Novel therapies often fail to reach the bedside due to low trial recruitment rates. Prior to conducting one of the first chimeric antigen receptor (CAR) T cell therapy trials in Canada, we used the Theoretical Domains Framework, a novel tool for identifying barriers and enablers...

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Bibliographic Details
Main Authors: Gisell Castillo, Manoj Lalu, Sarah Asad, Madison Foster, Natasha Kekre, Dean Fergusson, Terry Hawrysh, Harold Atkins, Kednapa Thavorn, Joshua Montroy, Stuart Schwartz, Robert Holt, Raewyn Broady, Justin Presseau, on behalf of the GO CART team
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Trials
Subjects:
Chimeric antigen receptor T cell therapy
Physician screening
Barriers to trial recruitment
Theoretical domains framework
Early phase clinical trials
Early phase immunotherapy trials
Online Access:https://doi.org/10.1186/s13063-021-05121-y

Internet

https://doi.org/10.1186/s13063-021-05121-y

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