Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM.

Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM.

We identified a key oncogenic pathway underlying neuroblastoma progression: specifically, MYCN, expressed at elevated level, transactivates the miRNA 17-5p-92 cluster, which inhibits p21 and BIM translation by interaction with their mRNA 3' UTRs. Overexpression of miRNA 17-5p-92 cluster in MYCN...

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Bibliographic Details
Main Authors: Laura Fontana, Micol E Fiori, Sonia Albini, Loredana Cifaldi, Serena Giovinazzi, Matteo Forloni, Renata Boldrini, Alberto Donfrancesco, Valentina Federici, Patrizio Giacomini, Cesare Peschle, Doriana Fruci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2375057?pdf=render

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http://europepmc.org/articles/PMC2375057?pdf=render

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