Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids

The use of organoids in personalized medicine is promising but high throughput platforms are needed. Here the authors develop an automated, high-throughput, microfluidic 3D organoid culture system that allows combinatorial and dynamic drug treatments and real-time analysis of organoids.

Bibliographic Details
Main Authors:	Brooke Schuster, Michael Junkin, Sara Saheb Kashaf, Isabel Romero-Calvo, Kori Kirby, Jonathan Matthews, Christopher R. Weber, Andrey Rzhetsky, Kevin P. White, Savaş Tay
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19058-4

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spelling	doaj-438a4d38d7d84d97b586b8ca0dd0e9232021-05-11T08:02:31ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-19058-4Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoidsBrooke Schuster0Michael Junkin1Sara Saheb Kashaf2Isabel Romero-Calvo3Kori Kirby4Jonathan Matthews5Christopher R. Weber6Andrey Rzhetsky7Kevin P. White8Savaş Tay9Pritzker School of Molecular Engineering, The University of ChicagoPritzker School of Molecular Engineering, The University of ChicagoPritzker School of Molecular Engineering, The University of ChicagoInstitute for Genomics and Systems Biology, The University of ChicagoInstitute for Genomics and Systems Biology, The University of ChicagoPritzker School of Molecular Engineering, The University of ChicagoDepartment of Pathology, The University of Chicago MedicineInstitute for Genomics and Systems Biology, The University of ChicagoInstitute for Genomics and Systems Biology, The University of ChicagoPritzker School of Molecular Engineering, The University of ChicagoThe use of organoids in personalized medicine is promising but high throughput platforms are needed. Here the authors develop an automated, high-throughput, microfluidic 3D organoid culture system that allows combinatorial and dynamic drug treatments and real-time analysis of organoids.https://doi.org/10.1038/s41467-020-19058-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Brooke Schuster Michael Junkin Sara Saheb Kashaf Isabel Romero-Calvo Kori Kirby Jonathan Matthews Christopher R. Weber Andrey Rzhetsky Kevin P. White Savaş Tay
spellingShingle	Brooke Schuster Michael Junkin Sara Saheb Kashaf Isabel Romero-Calvo Kori Kirby Jonathan Matthews Christopher R. Weber Andrey Rzhetsky Kevin P. White Savaş Tay Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids Nature Communications
author_facet	Brooke Schuster Michael Junkin Sara Saheb Kashaf Isabel Romero-Calvo Kori Kirby Jonathan Matthews Christopher R. Weber Andrey Rzhetsky Kevin P. White Savaş Tay
author_sort	Brooke Schuster
title	Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
title_short	Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
title_full	Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
title_fullStr	Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
title_full_unstemmed	Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
title_sort	automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	The use of organoids in personalized medicine is promising but high throughput platforms are needed. Here the authors develop an automated, high-throughput, microfluidic 3D organoid culture system that allows combinatorial and dynamic drug treatments and real-time analysis of organoids.
url	https://doi.org/10.1038/s41467-020-19058-4
work_keys_str_mv	AT brookeschuster automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT michaeljunkin automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT sarasahebkashaf automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT isabelromerocalvo automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT korikirby automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT jonathanmatthews automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT christopherrweber automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT andreyrzhetsky automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT kevinpwhite automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids AT savastay automatedmicrofluidicplatformfordynamicandcombinatorialdrugscreeningoftumororganoids
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Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids

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