Secreted Clusterin Gene Silencing Enhances Chemosensitivity of A549 Cells to Cisplatin Through AKT and ERK1/2 Pathways in Vitro

Secreted Clusterin Gene Silencing Enhances Chemosensitivity of A549 Cells to Cisplatin Through AKT and ERK1/2 Pathways in Vitro

Background/Aims: Several studies have shown secreted clusterin (sCLU) silencing directed against sCLU mRNA in sCLU-rich lung cancer cell lines sensitized cells to chemotherapy. However, the molecular mechanisms underlying the effect of sCLU silencing on lung cancer cell chemosensitivity is not known...

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Bibliographic Details
Main Authors: Biyuan Zhang, Kejun Zhang, Zimin Liu, Fengyun Hao, Mei Wang, Xiangchun Li, Zongsiu Yin, Hui Liang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Lung cancer
Chemotherapy
Clusterin
Cisplatin
AKT
ERK1/2
Online Access:http://www.karger.com/Article/FullText/358685

Internet

http://www.karger.com/Article/FullText/358685

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