Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry

Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry

Breast stroma plays a significant role in breast cancer risk and progression yet remains poorly understood. In breast stroma, collagen is the most abundantly expressed protein and its increased deposition and alignment contributes to progression and poor prognosis. Collagen post-translation modifica...

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Bibliographic Details
Main Authors: Denys Rujchanarong, Julia Lefler, Janet E. Saunders, Sarah Pippin, Laura Spruill, Jennifer R. Bethard, Lauren E. Ball, Anand S. Mehta, Richard R. Drake, Michael C. Ostrowski, Peggi M. Angel
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
imaging mass spectrometry (IMS)
immunohistochemistry (IHC)
PTEN
stroma
ECM
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/17/4419

Internet

https://www.mdpi.com/2072-6694/13/17/4419

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