TGF-β1 Receptor Inhibitor SB525334 Attenuates the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells via the TGF-β1 Signaling Pathway

TGF-β1 Receptor Inhibitor SB525334 Attenuates the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells via the TGF-β1 Signaling Pathway

We investigated the effect of SB525334 (TGF<b>-</b>β receptor type 1 (TβRI) inhibitor) on the epithelial to mesenchymal transition (EMT) signaling pathway in human peritoneal mesothelial cells (HPMCs) and a peritoneal fibrosis mouse model. In vitro experiments were performed using HPMCs....

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Bibliographic Details
Main Authors: Jung-Yoon Heo, Jun-Young Do, Yunmee Lho, A-Young Kim, Sang-Woon Kim, Seok-Hui Kang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomedicines
Subjects:
SB525334
epithelial mesenchymal transition
transforming growth factor-beta1
peritoneal fibrosis
peritoneal mesothelial cell
Online Access:https://www.mdpi.com/2227-9059/9/7/839

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https://www.mdpi.com/2227-9059/9/7/839

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