Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease
Introduction: Parkinson’s disease (PD) is a chronic illness which damages central and peripheral nervous system. The presence of peripheral neuropathy (PN) in PD, it has been suggested to be the effect of treatment. The aim of this study was to investigate autonomic cardiac control in PD patients wi...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Romanian Association of Balneology, Editura Balneara
2019-02-01
|
Series: | Balneo Research Journal |
Subjects: | |
Online Access: | http://bioclima.ro/Balneo240.pdf |
id |
doaj-44272cdcb30a43a88719c13fcfc932ba |
---|---|
record_format |
Article |
spelling |
doaj-44272cdcb30a43a88719c13fcfc932ba2020-11-24T21:12:41ZengRomanian Association of Balneology, Editura BalnearaBalneo Research Journal2069-75972069-76192019-02-01101556110.12680/balneo.2019.240Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's diseaseDaniela Matei0Catalina Luca1Doru Andritoi2Robert Fuior3Dan Zaharia4Ilie Onu5Calin Corciova6Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, RomaniaIntroduction: Parkinson’s disease (PD) is a chronic illness which damages central and peripheral nervous system. The presence of peripheral neuropathy (PN) in PD, it has been suggested to be the effect of treatment. The aim of this study was to investigate autonomic cardiac control in PD patients with normal serum levels of vitamin B12 by means of spectral analysis of short-term heart rate variability (HRV) and also to assess the prevalence of PN using electrophysiological examinations. Methods: 30 (18 male and 12 female) with PD were compared to 20 age- and sex-matched control subjects. Short-term ECG was used to calculate time domain and spectral parameters of HRV. The stimulodetection examination was realized in the motor fibers of median, peroneal and tibial nerves, and in the sensitive fibers of median and sural nerve according to the standard procedures. Results: Low and high frequency were lower in PD patients than in controls (LF: 332.±288.4 ms² PD vs 723.9±348.2 ms2 C; HF: 283.72±241.97 ms² PD vs 530.54±226.5 ms² C, p<0.01). No differences between LF/HF ratio of PD and controls appeared. Sensory nerve action potential in sural nerve was reduced in PD patients. No differences between sensory and motor nerve conduction velocities of PD and controls appeared. Conclusions: PD causes dysfunction of autonomic cardiovascular regulation and peripheral nerve involvement. http://bioclima.ro/Balneo240.pdfParkinson’s diseaseheart rate variabilityparasympathetic nervous systemlow frequencysensory nerve action potentialnerve conduction velocity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniela Matei Catalina Luca Doru Andritoi Robert Fuior Dan Zaharia Ilie Onu Calin Corciova |
spellingShingle |
Daniela Matei Catalina Luca Doru Andritoi Robert Fuior Dan Zaharia Ilie Onu Calin Corciova Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease Balneo Research Journal Parkinson’s disease heart rate variability parasympathetic nervous system low frequency sensory nerve action potential nerve conduction velocity |
author_facet |
Daniela Matei Catalina Luca Doru Andritoi Robert Fuior Dan Zaharia Ilie Onu Calin Corciova |
author_sort |
Daniela Matei |
title |
Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease |
title_short |
Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease |
title_full |
Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease |
title_fullStr |
Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease |
title_full_unstemmed |
Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease |
title_sort |
autonomic dysfunction and peripheral nerve involvement in patients with parkinson's disease |
publisher |
Romanian Association of Balneology, Editura Balneara |
series |
Balneo Research Journal |
issn |
2069-7597 2069-7619 |
publishDate |
2019-02-01 |
description |
Introduction: Parkinson’s disease (PD) is a chronic illness which damages central and peripheral nervous system. The presence of peripheral neuropathy (PN) in PD, it has been suggested to be the effect of treatment. The aim of this study was to investigate autonomic cardiac control in PD patients with normal serum levels of vitamin B12 by means of spectral analysis of short-term heart rate variability (HRV) and also to assess the prevalence of PN using electrophysiological examinations. Methods: 30 (18 male and 12 female) with PD were compared to 20 age- and sex-matched control subjects. Short-term ECG was used to calculate time domain and spectral parameters of HRV. The stimulodetection examination was realized in the motor fibers
of median, peroneal and tibial nerves, and in the sensitive fibers of median and sural nerve according to the standard procedures. Results: Low and high frequency were lower in PD patients than in controls (LF: 332.±288.4 ms² PD vs 723.9±348.2 ms2 C; HF: 283.72±241.97 ms² PD vs 530.54±226.5 ms² C, p<0.01). No
differences between LF/HF ratio of PD and controls appeared. Sensory nerve action potential in sural nerve was reduced in PD patients. No differences between sensory and motor nerve conduction velocities of PD and controls appeared. Conclusions: PD causes dysfunction of autonomic cardiovascular regulation and peripheral
nerve involvement. |
topic |
Parkinson’s disease heart rate variability parasympathetic nervous system low frequency sensory nerve action potential nerve conduction velocity |
url |
http://bioclima.ro/Balneo240.pdf |
work_keys_str_mv |
AT danielamatei autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease AT catalinaluca autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease AT doruandritoi autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease AT robertfuior autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease AT danzaharia autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease AT ilieonu autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease AT calincorciova autonomicdysfunctionandperipheralnerveinvolvementinpatientswithparkinsonsdisease |
_version_ |
1716750171379859456 |