Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies

Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in cancers. In glutamine dependent cancer cells, mor...

Full description

Bibliographic Details
Main Authors: Zhefang Wang, Fanyu Liu, Ningbo Fan, Chenghui Zhou, Dai Li, Thomas Macvicar, Qiongzhu Dong, Christiane J. Bruns, Yue Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
glutaminolysis
cancer metabolism
metastasis
glutaminase inhibitor
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.589508/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.589508/full

Similar Items