Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates

Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates

Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy number, KIR3DL3 is ubiquitously present in every individual across diverse populations. No ligand or function is known for KIR3DL...

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Bibliographic Details
Main Authors: Laura A. Leaton, Jonathan Shortt, Katherine M. Kichula, Sudan Tao, Neda Nemat-Gorgani, Alexander J. Mentzer, Stephen J. Oppenheimer, Zhihui Deng, Jill A. Hollenbach, Christopher R. Gignoux, Lisbeth A. Guethlein, Peter Parham, Mary Carrington, Paul J. Norman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
KIR3DL3
NK cells
KIR
HLA class I
comparative evolution
infectious disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00024/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00024/full

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