Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease

Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease

Niemann-Pick type C (NPC) disease is a multisystem disorder resulting from mutations in the NPC1 gene that encodes a protein involved in intracellular cholesterol trafficking. Significant liver dysfunction is frequently seen in patients with this disease. The current studies used npc1 mutant mice to...

Full description

Bibliographic Details
Main Authors: Eduardo P. Beltroy, Benny Liu, John M. Dietschy, Stephen D. Turley
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Journal of Lipid Research
Subjects:
hepatic dysfunction
chylomicron cholesterol
low density lipoprotein receptor
biliary bile acid
hepatomegaly
small intestine
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434406

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520434406

Similar Items