1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.

1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.

The emergence of regulatory T cells (Tregs) as central mediators of peripheral tolerance in the immune system has led to an important area of clinical investigation to target these cells for the treatment of autoimmune diseases such as type 1 diabetes. We have demonstrated earlier that in vitro trea...

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Bibliographic Details
Main Authors: Tom L Van Belle, An-Sofie Vanherwegen, Dorien Feyaerts, Pierre De Clercq, Annemieke Verstuyf, Hannelie Korf, Conny Gysemans, Chantal Mathieu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4184870?pdf=render

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http://europepmc.org/articles/PMC4184870?pdf=render

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