Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme

Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme

Protein tyrosine phosphatase non-receptor 12 (PTPN12) is an important protein tyrosine phosphatase involved in regulating cell adhesion and migration as well as tumorigenesis. Here, we solved a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual...

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Bibliographic Details
Main Authors: Hui Dong, Francesco Zonta, Shanshan Wang, Ke Song, Xin He, Miaomiao He, Yan Nie, Sheng Li
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
PTPN12
molecular dynamics
structure
Online Access:https://www.mdpi.com/1422-0067/19/1/60

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https://www.mdpi.com/1422-0067/19/1/60

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