Comparison of Eight Technologies to Determine Genotype at the UGT1A1 (TA)<sub>n</sub> Repeat Polymorphism: Potential Clinical Consequences of Genotyping Errors?

To ensure accuracy of <i>UGT1A1 (TA)<sub>n</sub></i> (rs3064744) genotyping for use in pharmacogenomics-based irinotecan dosing, we tested the concordance of several commonly used genotyping technologies. Heuristic genotype groupings and principal component analysis demonstra...

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Main Authors: Tristan M. Sissung, Roberto H. Barbier, Douglas K. Price, Teri M. Plona, Kristen M. Pike, Stephanie D. Mellott, Ryan N. Baugher, Gordon R. Whiteley, Daniel R. Soppet, David Venzon, Arlene Berman, Arun Rajan, Giuseppe Giaccone, Paul Meltzer, William D. Figg
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/3/896