Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat

<p>Abstract</p> <p>Background</p> <p>Cerebral ischemia is usually characterized by a reduction in local blood flow and metabolism and by disruption of the blood-brain barrier in the infarct region. The formation of oedema and opening of the blood-brain barrier in stroke...

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Bibliographic Details
Main Authors: Maddahi Aida, Chen Qingwen, Edvinsson Lars
Format: Article
Language:English
Published: BMC 2009-06-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/10/56