Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria
Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD...
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doaj-46d52e60a741489986bd7fa59c0fd3ec2020-11-25T01:02:19ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792020-01-01202010.1155/2020/96920309692030Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic CriteriaKevin John John0Mohammad Sadiq1Tina George2Karthik Gunasekaran3Nirmal Francis4Ebenezer Rajadurai5Thambu David Sudarsanam6Department of Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Medicine, Christian Medical College, Vellore 632004, IndiaMixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study. A clinical diagnosis of MCTD was made in 111 patients, of whom 103 (92.8%) were women. The mean age at presentation was 39.3 years (SD±11.6). The most common organ systems that were involved were musculoskeletal system (95.5%), skin and mucosa (78.4%), and the gastrointestinal and hepatobiliary systems (56%). The maximum sensitivity was for the Kasukawa criteria with a sensitivity of 77.5% (95% CI 68.4-84.6) and specificity of 92.2% (95% CI 87-95.5). The Kahn criteria and Alarcón-Segovia criteria had the maximum specificity; the Alarcón-Segovia criteria had a sensitivity of 69.4% (95% CI 59.8-77.6) and a specificity of 99.4% (95% CI 96.5-99.9), while the Kahn criteria had a sensitivity of 52.3% (95% CI 42.6-61.7) and a specificity of 99.4% (95% CI 96.5-99.9). The sensitivity and specificity of Sharp criteria were 57.7% (95% CI 47.9-66.87) and 90% (95% CI 84.4-93.8), respectively.http://dx.doi.org/10.1155/2020/9692030 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kevin John John Mohammad Sadiq Tina George Karthik Gunasekaran Nirmal Francis Ebenezer Rajadurai Thambu David Sudarsanam |
spellingShingle |
Kevin John John Mohammad Sadiq Tina George Karthik Gunasekaran Nirmal Francis Ebenezer Rajadurai Thambu David Sudarsanam Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria International Journal of Rheumatology |
author_facet |
Kevin John John Mohammad Sadiq Tina George Karthik Gunasekaran Nirmal Francis Ebenezer Rajadurai Thambu David Sudarsanam |
author_sort |
Kevin John John |
title |
Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria |
title_short |
Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria |
title_full |
Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria |
title_fullStr |
Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria |
title_full_unstemmed |
Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria |
title_sort |
clinical and immunological profile of mixed connective tissue disease and a comparison of four diagnostic criteria |
publisher |
Hindawi Limited |
series |
International Journal of Rheumatology |
issn |
1687-9260 1687-9279 |
publishDate |
2020-01-01 |
description |
Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study. A clinical diagnosis of MCTD was made in 111 patients, of whom 103 (92.8%) were women. The mean age at presentation was 39.3 years (SD±11.6). The most common organ systems that were involved were musculoskeletal system (95.5%), skin and mucosa (78.4%), and the gastrointestinal and hepatobiliary systems (56%). The maximum sensitivity was for the Kasukawa criteria with a sensitivity of 77.5% (95% CI 68.4-84.6) and specificity of 92.2% (95% CI 87-95.5). The Kahn criteria and Alarcón-Segovia criteria had the maximum specificity; the Alarcón-Segovia criteria had a sensitivity of 69.4% (95% CI 59.8-77.6) and a specificity of 99.4% (95% CI 96.5-99.9), while the Kahn criteria had a sensitivity of 52.3% (95% CI 42.6-61.7) and a specificity of 99.4% (95% CI 96.5-99.9). The sensitivity and specificity of Sharp criteria were 57.7% (95% CI 47.9-66.87) and 90% (95% CI 84.4-93.8), respectively. |
url |
http://dx.doi.org/10.1155/2020/9692030 |
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